The Effects of Epithalon

Epithalon as Sleep Aid

Epithalon is a synthetic peptide that is just four amino acids long (Alanine-Glutamate-Asparagine-Glycine) and was originally isolated from cow pineal gland. Despite its small size, epithalon has been found to have some amazing effects. It is being widely tested for its anti-cancer, anti-aging, and sleep-regulating effects.

Epithalon as Cancer Therapy.

Studies suggest that even small doses of epithalon are effective in prolonging the lives of mice suffering from certain forms of cancer. It has also been found to suppress cancer formation in mice that are genetically prone to certain tumors. In particular, epithalon is being developed as a potential treatment for breast cancers that express the HER-2/neu gene mutation1. More recent research suggests that epithalon may also prevent the development of spontaneous tumors in the testicle as well as leukemias2,3.

Eipthalon as Fountain of Youth

Epithalon has been shown to activate the enzyme telomerase, which is responsible for maintaining the integrity of telomeres. Telomeres cap the ends of chromosomes and because chromosomes shorten each time they are replicated for cell division, eventually disappear. To prevent DNA damage from occurring, cells with telomeres that are too short are killed off. This process, known as apoptosis, occurs in most human and mammalian cells and is part of the reason that organisms age. Telomerase repairs telomeres and thus prevents apoptosis and its aging effects from occurring. By activating telomerase, epithalon can ward off at least some of the effects of aging such as loss of skin tone, loss of muscle mass, vision changes, etc.

Another way in which epithalon wards of aging is through stimulation of the immune system. In normal aging, the thymus, the gland responsible for T-cell production, losses function. Without new T-cells, the body has difficulty fighting off new infections, particularly infections that it has never encountered before. By protecting the thymus and boosting its function, epithalon helps the body to maintain a healthy immune system.

Epithalon as Sleep Aid

Epithalon as Sleep Aid

Epithalon can influence melatonin release in rats, thus affecting sleep quality, the rate of onset of sleep, and sleep duration. Epithalon is so effective in improving sleep that it produces better results than direct melatonin supplementation in tests on rats. By improving sleep, epithalon helps to improve hormone profiles and even fight off premature aging4.


1. Anisimov, V. N., Khavinson, V. K., Alimova, I. N., Semchenko, A. V. & Yashin, A. I. Epithalon decelerates aging and suppresses the development of breast adenocarcinomas in transgenic her-2/neu mice. Bull. Exp. Biol. Med.134, 187-190 (2002). visit for more detailed information.

2. Vinogradova, I. A. et al. Geroprotective effect of ala-glu-asp-gly peptide in male rats exposed to different illumination regimens. Bull. Exp. Biol. Med.145, 472-477 (2008).

3. Vinogradova, I. A. et al. Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes. Bull. Exp. Biol. Med.144, 825-830 (2007).

4. Arutjunyan, A. et al. Melatonin and pineal gland peptides are able to correct the impairment of reproductive cycles in rats. Curr. Aging Sci.5, 178-185 (2012).

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